国际权威再认证!我院三篇最新科研论文闪耀亚太风湿年会舞台
亚太风湿病学会(APLAR)年会
2024年盛夏之际,即8月21日-25日,第26届亚太风湿病学会(APLAR)年会将在新加坡璀璨启幕。届时,来自世界各地的顶尖风湿病专家将汇聚一堂,共同分享他们在科研探索中的最新成果、及临床治疗中的宝贵经验,为参会者提供一个绝佳的世界级学术交流平台。
继2023年我院两篇论文成功被APLAR年会收录之后(喜报!第二十五届亚太风湿病学大会年会收录我院论文),近日再次传来喜讯——我院三篇科研论文被正式录用为壁报交流项目。
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【论文题目】《Surgical removal of gout stones from both feet and knees:A case report》(双足及膝关节行痛风石摘除手术病例报告1例)
【所有作者】陈建春
论文①正文展示
Background:We hereby report the case of a 47 years old male who reported polyarticular pain for 15+years with exacerbation for 1+years.Physical examination showed multiple gout stones of the size of a goose egg in the joints of both feet and small egg-sized gout stones in the joints of both knees(Fig1).DR films showed the results as in Fig2.Laboratory investigations:uric acid:556.7μmol/L;creatinine:195.9μmol/L;ultrasensitive-C-reactive protein:5.86 mg/L;homocysteine:38.33μmol/L;urea:9.88 mmol/L;cystatin C:3.55 mg/L,and no other abnormalities.Diagnosis:gout;staging:gouty stone stage.She had taken double knee surgery in the local hospital,which led to tendon destruction and abnormal walking.
我们在此报告一个47岁男性的病例,他自述多关节疼痛15+年,加重1+年。查体显示双足关节形成鹅蛋大小痛风石多个,双膝关节形成小鸡蛋大小痛风石(图1)。DR片显示结果如图2。实验室检查:尿酸:556.7μmol/L;肌酐:195.9μmol/L;超敏-C反应蛋白:5.86mg/L;同型半胱氨酸:38.33μmol/L;尿素:9.88 mmol/L;胱抑素C:3.55 mg/L,其余未见异常。诊断:痛风;分期:痛风石期。曾在当地医院采取双膝手术,导致肌腱破坏,走路异常。
Methods:The long-term high uric acid state of the patient may cause damage to the kidneys,leading to a decrease in glomerular filtration rate,which in turn affects the excretion of creatinine,so that the patient's creatinine level has always been very high,with a maximum of more than 200μmol/L.Therefore,before the gouty stone removal operation,we carried out a combination of traditional Chinese and Western medicine to regulate the patient's renal function.Three months later,the patient's creatinine level was stabilized at 150μmol/L,and the patient was treated with gout lesion removal and arthroscopic joint treatment.
患者长期处于高尿酸状态,可能对肾脏造成损害,导致肾小球滤过率下降,进而影响肌酐的排泄,以至于患者的肌酐水平一直很高,最高超过200μmol/L。所以,在进行痛风石摘除手术之前,我们对患者肾功能进行中西医结合调理。三个月后,患者的肌酐水平稳定在150μmol/L,我们予以患者痛风病灶切除及针刀镜关节治疗。
Results:The patient adapted well in performing gout stone removal and the operation was completed successfully(Fig3-4).Comparison of daily living ability scale scores before and after treatment:preoperative 80 points grade 1;1 month after the operation,100 points grade 0,daily living ability completely self-care.
患者在行痛风石摘除术中适应良好,手术顺利完成(图3)。治疗前后日常生活能力评定量表评分对比:术前80分1级;术后1个月,100分0级,日常生活能力完全自理。
Conclusion:Surgical treatment is a viable option in the management of gout stones in the feet and knees and can significantly improve patient symptoms and quality of life.However,surgical treatment is not suitable for all patients with gouty stones and needs to be evaluated and decided based on the patient's overall condition,the severity of the disease and the risk of surgery.Despite the positive outcome of this case,further studies and long-term follow-up are needed to evaluate the long-term efficacy and safety of surgical treatment in the management of systemic multiple gouty stones.In addition,a combination of pharmacologic and lifestyle interventions has an important role to play in the management of gouty stones.
外科治疗在处理双足及膝关节痛风石时是一个可行选择,并可以显著改善患者症状和生活质量。然而,外科治疗并非适用于所有痛风石患者,需要根据患者整体状况、病情严重程度和手术风险来进行评估和决策。尽管本病例的治疗结果积极,但仍需要进一步研究和长期随访来评估外科治疗在全身多发性痛风石管理中的长期效果和安全性。此外,综合药物治疗和生活方式干预在管理痛风石方面也具有重要作用。
图1.查体显示双足关节形成鹅蛋大小痛风石多个,双手指关节形成鹌鹑蛋大小痛风石,双膝关节形成小鸡蛋大小痛风石
图2.DR片显示双足关节形成鹅蛋大小痛风石多个,双手指关节形成鹌鹑蛋大小痛风石伴握拳受限135°,双膝关节形成小鸡蛋大小痛风石
图3.痛风石摘除外科手术治疗中
图4.肾功能指标的变化(部分)
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【论文题目】《A case of bone and joint exposure after repairing gouty stone with joint infection by suture traction skin dilation》(缝线牵引皮肤扩张法修复踝部痛风石合并关节感染术后骨关节外露1例)
【所有作者】周攀
论文②正文展示
Purpose:Gouty stone is formed by the long-term deposition of urate,and the ankle is the common site of gouty stone.Due to the low subcutaneous fat and thin soft tissue,once there is soft tissue defect,it is easy to expose bones,tendons and other tissues,causing infection and even disability.This case will analyze the treatment of an ankle gouty stone with joint infection and exposed joints,and provide clinical treatment ideas for such diseases.
目的:痛风是由于体内的尿酸分泌增多和(或)排泄障碍,引起尿酸盐在关节周围逐渐沉积并产生钙化,后逐渐发展为痛风石。足踝部是痛风石常见生成部位,且因皮下脂肪少,软组织薄,一旦出现软组织缺损,容易造成骨骼、肌腱等组织外露的情况,引起感染,甚至致残。本案例将针对踝部痛风石合并关节感染骨关节外露患者的治疗进行分析,为此类病症提供临床治疗思路。
Methods:The patient,a 36-year-old male,underwent ankle incision and drainage in orthopedic hospital due to the right ankle gout stone.The wound remained unhealed for 13 days after the operation.White urate and yellowish tissue fluid exudated from the operative mouth,the surrounding tissue was red and swollen,skin temperature was high,tenderness was obvious,and ankle joint mobility was limited.Diagnosis:right ankle gouty with suppurative arthritis.On May 27,2022,debridment and drainage of right ankle joint under lumbar anesthesia+wound exclusion+gout lesion excision+acuposcopic joint treatment were performed.After treatment,the residual irregular wound of about 18cm×8cm×3cm from the posterior ankle to the lower leg was controlled by infection,and the ankle joint was exposed.On June 28,2022,the right medial malleolus underwent debridement suture and skin dilation.After the operation,the suture was fixed every day until the wound was covered,which lasted about 13 days.Finally,the skin was sutured again under local anesthesia to close the wound.
方法:患者36岁,男性,因右踝部痛风石在当地骨科医院行踝部切开引流术,术后伤口感染有痛风石及脓性分泌物自切口流出,伤口经久不愈达13天,术口可见白色尿酸盐及淡黄色组织液渗出,术口周围组织红肿,皮温高,触痛明显,踝关节活动功能受限。诊断:右踝部痛风石并化脓性关节炎。于2022年5月27日,在腰麻下行右踝关节清创引流+创面旷置术+痛风石病灶切除术+针刀镜关节治疗,经治疗感染控制后踝部至小腿下段残余约18cm×8cm×3cm的不规则创面,踝关节外露。于2022年6月28日在腰麻下行右内踝清创缝合术,外踝清创,皮肤扩张术。术后每日牵拉缝线后固定直至覆盖创面,历时约13天,最后在局麻下再次缝合皮肤闭合创面。
Results:After treatment,the patient's right ankle joint healed well,no blood or fluid seepage,no swelling and tenderness in the back of the foot,normal movement of the distal extremity of the affected limb,good active and passive flexion and extension of the ankle joint,little scar in the operative area,and no abnormal sensation in the ankle and back of the foot.
结果:患者经治疗后,右踝关节术口愈合良好,无渗血、渗液,足背无肿胀压痛,患肢肢体远端活动感觉正常,踝关节主被动屈伸活动良好,术区疤痕小,踝部及足背感觉无异常。
Conclusion:Suture traction skin expansion can make full use of limited skin resources,without increasing scars,without damaging the donor area,so that the repaired skin is exactly the same as normal skin tissue in texture,color,touch and function.Compared with common skin dilation,it has the advantages of simple operation,short treatment period and flexible adjustment to repair irregular wounds.Suture traction skin dilatation is a method worthy of promotion and application because of its low cost and remarkable therapeutic effect.
结论:缝线牵引皮肤扩张术可充分利用有限的皮肤资源,在不增加瘢痕的前提下,对供区不会造成损伤,使修复后的皮肤在质地、色泽、触感和功能上与正常的皮肤组织完全相同。与常见的皮肤扩张相比,有操作简便,治疗周期短,能灵活调整修复不规则创面的优点。缝线牵引皮肤扩张术所需费用少,治疗效果显著,是值得推广和应用的方法。
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【论文题目】《Analysis of seasonal differences in recurrent episodes of rheumatoid arthritis》(类风湿关节炎反复发作的季节性特征)
【所有作者】王华
论文③正文展示
Background:Rheumatoid arthritis(RA)is a chronic autoimmune disease characterized by joint destruction,inflammatory synovitis,and pannus formation.The normal operation of the viscera and meridians of the human body is inseparable from the warming,promoting and stimulating effects of Yang Qi.During the four seasons,the climate is changeable.When the body is dysfunctional and unable to adapt to periodic changes in the external environment,it will cause disease.In the course of a day,there is a close relationship between disease and climate change in nature,which changes with the increase and decrease of Yang,the so-called"morning is lighten,day is peaceful,evening is stronger,night is worse".Accordingly,in clinical practice,the symptoms of RA patients are often aggravated or alleviated due to seasonal alternations and temperature changes.
目的:类风湿关节炎(RA)是一种以关节破坏、炎症性滑膜炎和血管翳形成为特征的慢性风湿免疫性疾病。人体脏腑经络的正常运行离不开阳气的温煦、推动和激发作用。四季之时,气候变化无常。当机体功能失调,无法适应外部环境的周期性变化时,就会引发疾病。一日之中,疾病与自然界的气候变化之间存在着密切关系,随着阳气的增长与消退而发生变化,所谓“旦慧、昼安、夕加、夜甚”即是如此。相应地,在临床上经常会出现因季节交替及气温变化导致RA患者的症状有所加重或减轻。
Method:Consult relevant literature and make analysis.
方法:查阅相关文献,进行分析。
Results:RA is prone to relapse in clinical practice,and many studies have shown that RA is highly active in winter and spring.The possible reason is that the alternation of seasons causes latent pathogens in the body.Secondly,cold,wet and other climates and environments will promote the infiltration of inflammatory cells in the body and the proliferation of synovial cells,aggravating the symptoms of RA.In addition,the type and amount of intestinal flora and serum vitamin D content of RA patients also change with the alternations of seasons,which will affect the recurrence of RA.
结果:RA在临床中易于复发,许多研究结果显示,RA在冬春季活动度高。其可能原因是,季节交替引发体内伏邪致病。其次,寒冷、潮湿等气候、环境会促进体内炎症细胞的浸润和滑膜细胞的增生,加重RA的症状。此外,RA患者的肠道菌群的种类和数量以及血清维生素D的含量等也随季节的交替发生变化,都会影响RA的复发。
Conclusion:The diagnosis and treatment of diseases should pay attention to the influence of seasonal changes.There is a close relationship between human life activities and nature's seasons and climate changes.When the regulatory function of the body is abnormal,it is unable to make corresponding adjustments to the seasonal and climatic changes in nature,which will lead to the emergence of diseases.In spring,the use of natural Yang for treatment can effectively remove the cold evil in the body,so as to prevent the occurrence of diseases.Understanding the seasonal variation of the onset of rheumatoid arthritis is helpful for clinicians to develop appropriate prevention and treatment measures,and play an active role in the treatment of RA.
结论:疾病的诊治应注重季节变化的影响。人类的生命活动与自然界的季节、气候的变迁等有着密切的关系。当机体的调节功能失常,无法对自然界的季节和气候变化作出相应调节的时候,就会导致疾病的出现。春季时,利用自然中升发的阳气来进行治疗,可以有效地祛除体内的寒邪,从而预防疾病的发生。了解类风湿关节炎发病受季节变化的影响情况,有助于临床医生制定相应的防治措施,对RA的治疗起到积极作。
亚太风湿病联盟由亚太地区各国风湿病学学会组成,是亚太地区最具影响力的风湿病学专业机构之一。我院论文能够得到如此盛大且影响力巨大的国际性学术盛会的认可,这不仅是对我们科研实力与学术成果的高度肯定,更是激励我们持续创新、勇攀科学高峰的强大动力。这份荣誉不仅彰显了我们在风湿免疫病领域的研究深度与广度,也为我们搭建了与国际同行交流切磋的宝贵平台。
我们将以此为契机,进一步加强国际合作,深化科研探索,共同推动风湿免疫病领域的前沿研究,力求在疾病机制、诊断技术、治疗方法等方面取得新的突破。同时,我们也将致力于提升诊疗水平,通过引入更先进的治疗理念和技术手段,为更多患者提供更加精准、有效、个性化的治疗方案,帮助他们早日摆脱病痛,重获健康与幸福。